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利用毛細管電泳法同時分析六種高血脂藥製劑含量分析&以奈米粒子及特定的DNA片段分析血液檢體中的 daunomycin

為了解決Altria Group的問題，作者Manas Chakraborty 這樣論述：

Project 1Title: Simultaneous analysis of six statins in pharmaceuticals using capillary electrophoresis coupled with field amplified sample stacking-sweeping-MEKC.Abstract: A novel and economical method has been developed for the simultaneous analysis of fluvastatin (Fluva), atorvastatin (Atorva),

lovastatin (Lova), simvastatin (Simva), pravastatin (Prava) and rosuvastatin (Rosuva) in pharmaceuticals using capillary electrophoresis (CE) coupled with UV detector. Base hydrolysis was used to open lactone ring of lovastatin and simvastatin, administered as lactone prodrugs, in order to transform

these compounds to the corresponding β-hydroxyl acid forms during sample preparation. To enhance the sensitivity, a stacking method, field amplified sample stacking combined with sweeping-micellar electrokinetic chromatography (FASS-Sweeping-MEKC) was coupled with the CE method. This method was opt

imized using experimental design strategy. Optimized conditions were found to be at 80 mM phosphate buffer (pH 4.5) containing SDS concentration 100 mM and acetonitrile 35% (v/v). The limit of detection was found 25 ng/mL for Lova and Atorva while for Simva, Prava, Fluva and Rosuva it was 50 ng/mL.

The linearity of the detector response for each statin was within the concentration range from 150 ng/mL to 1000 ng/mL with a correlation coefficient greater than 0.9971. The method was found accurate and precise as the relative standard deviation (RSD) and relative error (RE) values were under ± 3

.7% and ± 2.7% respectively. Analyses of six statin drugs in pharmaceutical samples were carried out within 15 minutes. The method was further applied on pharmaceuticals to estimate drug content and the drug content percentage in three different concentrations was found under ± 5% which was under ac

ceptable range.Project 2Title: Development of fluorescence resonance energy transfer strategy based on aptamer coupled with carbon dot for biosensing of daunomycin in plasma..Abstract: A novel aptamer based carbon dot (CD) biosensor has been designed with the application of fluorescence resonance en

ergy transfer (FRET) for the estimation of daunomycin (DAN) in biological samples. Positively charged CD was synthesized using precursor citric acid (CA) and branched polyethylenimine MW 800 (BPEI 800) and the solvent used was ethylene glycol (EG). The positively charged CD got attached with the neg

atively charged DAN aptamer which on the other side captured the DAN. By exciting the CD with the help of the FRET the DAN could automatically be excited and the fluorescence could be observed, as the distance between the CD and DAN is reduced by the aptamer binding. Plasma samples were deproteinize

d using acetonitrile and was further reconstituted with acetonitrile after vaccum drying. The optimized condition was found at buffer concentration (TRIS-HCl) 20 mM, pH 7.4, CD dilution 5000 X, aptamer concentration 1 µM, reconstitution solvent acetonitrile and volume of acetonitrile 25 µL. The limi

t of detection was 250 ng/mL. The linearity response for DAN was within the concentration range from 1µg/mL to 10 µg/mL with a correlation coefficient greater than 0.9985. All the other parameters like accuracy, precision were under ± 10 % which was under acceptable range. This method offered very s

hort analysis time and use of only fluorescence spectrophotometer for detection and very simple sample pretreatment. The method was further applied on biological samples to estimate drug content.

建立毛細管電泳與高效能液相層析平台應用於食品安全檢測塑化劑與瘦肉精

為了解決Altria Group的問題，作者謝松裕 這樣論述：

本研究係建立毛細管電泳與高效能液相層析檢測平台，來對食品中的塑化劑與瘦肉精進行分析檢測。第一部分的研究，以毛細管電泳中的微乳化電動層析法(Microemulsion electrokinetic chromatography, MEEKC)搭配線上掃集濃縮技術(Sweeping)，並在微乳化電動層析法中的微乳液，加入具有高分子與界面活性劑特性的Pluronic® F-127做為共界面活性劑。研究結果證明，Pluronic® F-127能穩定微乳液的微胞並增加脂溶性化合物Bis(2-ethylhexyl) phthalate與Dibutyl phthalate的分離效率。而此兩種脂溶性化合物被

Sodium dodecyl sulfate的微胞包覆後，比較電動取樣與壓力進樣之感度，結果指出，電動取樣能增加25倍的感度。方法確效方面，此兩種脂溶性化合物的檢量線之相關係數皆大於0.999，而相對標準偏差值與相對誤差值均小於4.9%。本方法也順利應用於分析六種不同品牌的市售運動飲料，測定是否含有此兩種脂溶性化合物，其中一種市售運動飲料中被發現含有Bis(2-ethylhexyl) phthalate，並經液相層析串聯質譜儀驗證此結果。第二部分之研究，以高效能液相層析儀搭配固相萃取，建立同時分離九種鄰苯二甲酸酯類之分析方法，其偵測極限為0.5-10 ng/mL。檢量線分析之相關係數皆大於0.

990，而相對標準偏差值與相對誤差值均小於9.5%。將此方法應用於分析兩種不同品牌的市售茶包袋，發現此兩種市售茶包袋在熱水浸泡後含有Dibutyl phthalate，並以液相層析串聯質譜儀進行定性。第三部分之研究，為建立微胞電動層析法(Micellar electrokinetic chromatography, MEKC)搭配電場放大樣品堆積與掃集濃縮的兩種線上濃縮技術，來對動物飼料中的瘦肉精進行分析。利用陰離子界面活性劑Sodium di(2-ethylhexyl) sulfosuccinate能形成類似脂雙層微囊的結構來做為擬靜相，可對動物飼料中的八種瘦肉精完全分離，而與傳統的微胞電動

層析法方法比較，感度可增加400-2000倍。方法確效方面，八種瘦肉精在動物飼料中的偵測極限為5-20 ng/mL，檢量線分析之相關係數皆大於0.994，而相對標準偏差值與相對誤差值均小於12.7%。將本分析方法應用於分析四種不同品牌的市售動物飼料，並未監測到含有瘦肉精。