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利用毛細管電泳法同時分析六種高血脂藥製劑含量分析&以奈米粒子及特定的DNA片段分析血液檢體中的 daunomycin

為了解決Altria Group, Inc的問題，作者Manas Chakraborty 這樣論述：

Project 1Title: Simultaneous analysis of six statins in pharmaceuticals using capillary electrophoresis coupled with field amplified sample stacking-sweeping-MEKC.Abstract: A novel and economical method has been developed for the simultaneous analysis of fluvastatin (Fluva), atorvastatin (Atorva),

lovastatin (Lova), simvastatin (Simva), pravastatin (Prava) and rosuvastatin (Rosuva) in pharmaceuticals using capillary electrophoresis (CE) coupled with UV detector. Base hydrolysis was used to open lactone ring of lovastatin and simvastatin, administered as lactone prodrugs, in order to transform

these compounds to the corresponding β-hydroxyl acid forms during sample preparation. To enhance the sensitivity, a stacking method, field amplified sample stacking combined with sweeping-micellar electrokinetic chromatography (FASS-Sweeping-MEKC) was coupled with the CE method. This method was opt

imized using experimental design strategy. Optimized conditions were found to be at 80 mM phosphate buffer (pH 4.5) containing SDS concentration 100 mM and acetonitrile 35% (v/v). The limit of detection was found 25 ng/mL for Lova and Atorva while for Simva, Prava, Fluva and Rosuva it was 50 ng/mL.

The linearity of the detector response for each statin was within the concentration range from 150 ng/mL to 1000 ng/mL with a correlation coefficient greater than 0.9971. The method was found accurate and precise as the relative standard deviation (RSD) and relative error (RE) values were under ± 3

.7% and ± 2.7% respectively. Analyses of six statin drugs in pharmaceutical samples were carried out within 15 minutes. The method was further applied on pharmaceuticals to estimate drug content and the drug content percentage in three different concentrations was found under ± 5% which was under ac

ceptable range.Project 2Title: Development of fluorescence resonance energy transfer strategy based on aptamer coupled with carbon dot for biosensing of daunomycin in plasma..Abstract: A novel aptamer based carbon dot (CD) biosensor has been designed with the application of fluorescence resonance en

ergy transfer (FRET) for the estimation of daunomycin (DAN) in biological samples. Positively charged CD was synthesized using precursor citric acid (CA) and branched polyethylenimine MW 800 (BPEI 800) and the solvent used was ethylene glycol (EG). The positively charged CD got attached with the neg

atively charged DAN aptamer which on the other side captured the DAN. By exciting the CD with the help of the FRET the DAN could automatically be excited and the fluorescence could be observed, as the distance between the CD and DAN is reduced by the aptamer binding. Plasma samples were deproteinize

d using acetonitrile and was further reconstituted with acetonitrile after vaccum drying. The optimized condition was found at buffer concentration (TRIS-HCl) 20 mM, pH 7.4, CD dilution 5000 X, aptamer concentration 1 µM, reconstitution solvent acetonitrile and volume of acetonitrile 25 µL. The limi

t of detection was 250 ng/mL. The linearity response for DAN was within the concentration range from 1µg/mL to 10 µg/mL with a correlation coefficient greater than 0.9985. All the other parameters like accuracy, precision were under ± 10 % which was under acceptable range. This method offered very s

hort analysis time and use of only fluorescence spectrophotometer for detection and very simple sample pretreatment. The method was further applied on biological samples to estimate drug content.

肉鹼及其相關化合物之新型微萃取法開發

為了解決Altria Group, Inc的問題，作者陳易青 這樣論述：

肉鹼(3-羥基-4-三甲基氨丁酸)、丁基甜菜鹼(4-三甲基氨丁酸)及乙醯肉鹼(3-乙醯氧基-4-三甲基氨丁酸)是三種自然存在於人體內的四級銨物質。肉鹼是粒線體中脂肪酸氧化的重要輔助因子，因此被用來治療脂肪酸代謝不全的相關疾病，也用於輔助減肥。丁基甜菜鹼是人體內生性肉鹼的前驅物，和肉鹼的生合成有關聯。乙醯肉鹼為肉鹼之衍生物，其具有神經保護及清除自由基的功能。 在標準品中L-carnitine、acetyl-L-carnitine的定量範圍為10-2000 nM，在定量範圍有良好線性(r2>0.998)，偵測極限為4.5 fmol (S/N≧3)，並將建立之方法成功應用在化粧品、藥品及食品

中。由於L-carnitine、butyrobetaine及acetyl-L-carnitine為人體內生性物質，因此本實驗以標準添加法進行人體血漿中含量之定量分析，所得健康人體血漿中分析物濃度範圍分別為肉鹼：43.25-47.67 μM、丁基甜菜鹼：1.08-1.27 μM、乙醯肉鹼：2.79-6.65 μM。本方法的線性(r2>0.996)及再現性佳(斜率及截距RSD分別小於7.41%及9.06%)。顯示本研究成功地將反相液液微萃取法應用於肉鹼、丁基甜菜鹼及乙醯肉鹼等水溶性待測物的分析。