另外網站Alibaba Group ADR (BABA) aktie - Nordnet也說明:Køb Alibaba Group ADR (BABA) aktien. Hos Nordnet kan du handle fra 0 kr. i kurtage. Klik her for at følge aktiekursen i realtid.
國立陽明交通大學 藥理學研究所 李新城所指導 陳梅君的 Salubrinal在無葡萄糖環境下透過增加粒線體活性氧分子促進癌細胞死亡的調控機制 (2021),提出BABA ADR關鍵因素是什麼,來自於Salubrinal、xCT、葡萄糖剝奪、綜合壓力反應、活性氧分子。
而第二篇論文國立陽明大學 藥理學研究所 李新城、翁芸芳所指導 王笙帆的 氧基膽固醇與粒線體功能異常誘發人類肝癌及胃癌細胞化療抗藥性之分子機轉研究 (2016),提出因為有 癌症、氧基膽固醇、P型醣蛋白、粒線體功能異常、xCT、化療抗藥性的重點而找出了 BABA ADR的解答。
最後網站BABA - Alibaba Group Holding ADR Stock Price - Barchart.com則補充:Alibaba Group Holding ADR stocks price quote with latest real-time prices, charts, financials, latest news, technical analysis and opinions.
Salubrinal在無葡萄糖環境下透過增加粒線體活性氧分子促進癌細胞死亡的調控機制
為了解決BABA ADR 的問題,作者陳梅君 這樣論述:
葡萄糖是癌細胞的重要營養素。癌細胞會增加葡萄糖攝取、增強葡萄糖代謝相關酵素的表現、即使在氧氣充足的環境傾向以糖解作用代謝葡萄糖。當葡萄糖來源受限時,癌細胞會經由代謝重整,利用麩醯胺酸或其它營養素,以維持能量產生、生物質合成和氧化還原平衡。營養素缺乏也會活化整合性壓力反應以及下游的基因,包括xCT,以維持細胞平衡。xCT是細胞膜上cystine/glutamate反向運輸蛋白的輕鏈,其功能為藉由交換細胞內的glutamate,將細胞外的cystine運送入細胞內,作為glutathione合成的原料及維持氧化還原平衡。癌細胞在葡萄糖缺乏時,如何經由代謝重整調節氧化還原平衡,是癌症治療的重要議題
。本研究的目的,為研究癌細胞處於缺乏葡萄糖的環境時,整合性壓力反應及xCT在氧化還原平衡所扮演的角色。研究結果顯示,在無葡萄糖環境下,xCT的表現量和活性氧分子上升幅度以及細胞死亡率呈正相關。同時處理葡萄糖剝奪和Salubrinal(整合性壓力反應的活化劑)會增加xCT的表現。Salubrinal會進一步加強葡萄糖剝奪後,因粒線體氧化壓力所造成的細胞死亡。抗氧化劑N-acetylcysteine會降低粒線體內活性氧分子,減少細胞死亡。利用sulfasalazine (xCT抑制劑)抑制xCT的功能或利用sixCT降低xCT表現並不會增加,反而是減少細胞在葡萄糖剝奪時的氧化壓力。這顯示細胞在葡萄
糖剝奪時會依賴glutamate的代謝物維持氧化還原平衡。補充α-ketoglutarate (三羧酸循環的關鍵中間物) 也和抑制xCT類似,可以減少細胞氧化壓力和死亡的效果,這也強調了三羧酸循環的正常運作對細胞維持氧化還原平衡是必需的。本研究的結果顯示,同時處理Salubrinal和葡萄糖剝奪會增加xCT的表現並因而減少glutamate下游的代謝物,造成粒線體氧化壓力增加,導致細胞死亡。
氧基膽固醇與粒線體功能異常誘發人類肝癌及胃癌細胞化療抗藥性之分子機轉研究
為了解決BABA ADR 的問題,作者王笙帆 這樣論述:
癌症為世界上常見死因之一。在台灣,腸胃道腫瘤為國人常見罹患之癌症,如口腔癌、食道癌、胃癌、肝癌以及大腸直腸癌等。儘管現今醫療的進步,化學治療抗藥性仍是治療晚期癌症之重要課題。在本論文的第一部分,先前研究發現,膽固醇所導致細胞膜微環境的改變與化療抗藥性有關。7-ketocholesterol (7-KC)是一常見之氧基膽固醇,並且在癌症病患或是慢性肝病病患血液中有較高之7-KC。因此本研究推論氧基膽固醇 (如7-KC) 可能會影響肝癌細胞之化療抗藥性。在本論文的第二部分,粒線體是哺乳動物細胞中負責能量代謝之重要胞器,細胞能量代謝改變目前被認為是癌細胞的特徵之一。先前研究指出,在胃癌病患中,可發
現粒線體DNA有突變的現象,並可能進而產生粒線體功能異常,與癌症惡化及化療抗藥性有關。因此,本論文推論粒線體功能異常可能會在胃癌細胞中影響其化學治療抗藥性。 本論文第一部分研究是探討氧基膽固醇在肝癌中對於抗藥性的影響。本論文研究發現,不至於產生嚴重細胞毒性濃度之7-KC (非7α-hydroxycholesterol與cholesterol) 可使Huh-7及HepG2肝癌細胞減少細胞內doxorubicin之累積並降低其細胞毒性,但是對於初代肝細胞衍生之HuS-E/2細胞則無此影響。此外,研究發現,phosphatidylinositol 3-kinase (PI3K)-mammalian
target of rapamycin (mTOR) 路徑與7-KC所導致的P-glycoprotein (P-gp) 活性上升有關並且可透過活化PI3K-mTOR下游之蛋白質合成起始因子4E-BP1,轉錄後調控P-gp之表現。7-KC誘導P-gp排除能力增加是可逆性的,並可被LY294002 (PI3K inhibitor)、Akt inhibitor、rapamycin (mTOR inhibitor) 與mTOR knockdown所逆轉。然而7-KC所誘導之P-gp排除能力增加無法被抗氧化劑N-acetyl cysteine (NAC) 所逆轉。此外,7-KC可增加細胞內乳酸產生速率
,這暗示7-KC會使細胞代謝轉換成較偏好糖解反應,但是糖解反應抑制劑無法逆轉7-KC所活化之P-gp。以上這些結果指出,7-KC可透過PI3K- mTOR此訊息傳遞路徑調控P-gp並產生肝癌細胞之抗藥性,而7-KC造成之代謝改變與P-gp調控無關。 本論文第二部分研究為探討粒線體功能異常造成化療抗藥性之相關機制。先前研究結果指出,粒線體抑制劑oligomycin會產生cisplatin與doxorubicin抗藥性,然而詳細機轉尚未清楚。本研究發現,在具有cisplatin抗藥性之胃癌細胞,有代謝再造、粒線體變異、較高xCT之表現及具有較高含量之glutathuone (GSH) 等現象。並
且xCT抑制劑 (safasalazine 250 µM與erastin 1, 10 µM)、xCT siRNA或是GSH 合成抑制劑 (buthionine sulfoximine, BSO 0.5 mM) 皆可增加抗藥性胃癌細胞之cisplatin敏感性。在臨床檢體資料庫中,高度表現xCT對於接受輔助化療之胃癌病人有較差的預後。再者,在胃癌細胞中,粒線體功能異常可產生cisplatin抗藥性並增加xCT表現以及提高細胞內GSH的含量。xCT抑制劑 (sulfasalazine與erasin)、xCT siRNA或是BSO 皆可減少粒線體功能異常所產生的cisplatin抗藥性。研究結果進一
步指出,活化的eukaryotic initiation factor 2 (eIF2α) - the activating transcription factor 4 (ATF4) 訊息傳遞路徑主要可調控粒線體功能異常誘導xCT之表現。活化的eIF2α kinase general control nonderepressible-2 (GCN2),而非protein kinase R-like endoplasmic reticulum kinase (PERK),參與在粒線體功能異常所造成細胞內活性氧分子 (reactive oxygen species, ROS) 增加進而誘發eIF
2α-ATF4-xCT訊息傳遞路徑。這些結果指出,ROS所活化的GCN2-eIF2α-ATF4-xCT路徑參與在粒線體功能異常誘發cisplatin抗藥性的調控機轉之中。 根據本論文結果,7-KC所活化的PI3K-mTOR pathway在肝癌細胞中可當為一個預防P-gp誘導化療抗藥性之可能治療標的。並且ROS所活化的GCN2-eIF2α-ATF4-xCT pathway也可在胃癌細胞中當為一個可逆轉粒線體功能異常所導致化療抗藥性之潛在治療標的。
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... for their comments and valuable support and contribution to the ADR process. ... The team was ably led by Mohamed Nurul Alam and comprised Tupeni Baba, ... 於 books.google.com.tw -
#50.BABA: Alibaba Group Holding Ltd Stock Price Quote - New York
Stock analysis for Alibaba Group Holding Ltd (BABA:New York) including stock price, stock chart, company news, key statistics, fundamentals and company ... 於 www.bloomberg.com -
#51.Alibaba Group Holding Ltd ADR BABA Stock Quote
Get the latest Alibaba stock price (NYSE: BABA) and detailed information including news, historical charts and real-time prices, stock analyst information ... 於 www.morningstar.com -
#52.Alibaba: The 1 Billion Share Registration Isn't Dilution
First of all, the BABA shares traded on the Nasdaq are ADRs (American Depositary Receipts). What an ADR actually represents is not a direct ... 於 seekingalpha.com -
#53.Alibaba Investor Relations
Alibaba Investor Relations site contains information about Alibaba Corporation Inc and provides information about the business & financial information ... 於 www.alibabagroup.com -
#54.Baba 美股
新浪财经-美股频道为您提供阿里巴巴(baba)股票股价,股票实时行情,新闻, ... 鉅亨美股頻道提供你最完整的baba - 阿里巴巴集團adr、美股公司資料、美股 ... 於 didziojikinija.lt -
#55.$阿里巴巴(BABA)$ 有没有懂adr换股,,就是持有美股 - 老虎社区
san-$阿里巴巴(BABA)$ 有没有懂adr换股,,就是持有美股阿里巴巴的adr怎么换成即将在香港上市的股票. 於 laohu8.com -
#56.Alibaba Group - Wikipedia
Alibaba Group Holding Limited, also known as Alibaba (Chinese: 阿里巴巴), is a Chinese ... NYSE: BABA · SEHK: 9988 · Hang Seng Index component. 於 en.wikipedia.org -
#57.BABA - ALIBABA GROUP HOLDING-SP ADR - Valuesider
BABA stock - ALIBABA GROUP HOLDING-SP ADR stock ownership by value investors. List of tracked stock buys/sells/holdings from SEC reports, 13F quarterly ... 於 valuesider.com -
#58.BABA: Alibaba Group Holding Ltd ADR - ETFreplay
Data as of: Jan 25, 2023. BABA: Alibaba Group Holding Ltd ADR. Last Price; Dividend *; Yield *; Dividend Payments *. 120.25; $0.00; 0.00 %; 0. 於 www.etfreplay.com -
#59.Baba Stock Stockwits - Molinari Protection
Alibaba Group Holding Ltd (BABA). com New Year's SALE: Up to 40% OFF InvestingPro+ CLAIM OFFER Alibaba Group Holdings Ltd ADR (BABA) NYSE Create Alert Add ... 於 hiul.molinariprotection.it -
#60.<BABA>阿里巴巴-ADR-BABA-基本資料-MoneyDJ理財網
Alibaba Group Holding Limited(BABA.US,阿里巴巴集團控股有限公司)成立於1999年,總部位於中國杭州,為全球最大的電子商務集團,其業務包含廣告和行銷服務、電子支付、 ... 於 ctbcbank.moneydj.com -
#61.Alibaba Group Holding Ltd. ADR - onemarkets.hu
Name Alibaba Group Holding Ltd. ADR; ISIN US01609W1027; WKN A117ME; Reuters BABA.N; Bloomberg BABA UN Equity; Currency USD ... 於 www.onemarkets.hu -
#62.Alibaba Group Holding Limited (BABA.US) - 美股即時報價 ...
美股報價提供(包括:現價、升跌、升跌(%)、成交量、市值、前收市價/開市、波幅、市盈率(倍)/TTM、收益率/TTM、市賬率(倍)、資產淨值、最近派息、派息資訊、除淨日、派 ... 於 www.aastocks.com -
#63.阿里巴巴集團控股有限公司ADR(BABA)
公司名稱, ALIBABA GROUP HOLDING LTD. 所屬國家, HONG KONG. 所屬州. 所屬城市, CAUSEWAY BAY. 公司地址, 26/F TOWER ONE. 股票代碼, BABA. 所屬交易所, NYSE. 於 fund.scsb.com.tw -
#64.Alibaba ADR BABA.US - 歷史數據,股票報價和價格 - 市場動態
隨時隨地跟蹤、分享以及建立Alibaba ADR (BABA.US) 的模擬程式交易策略。超過100000+ 以上的交易策略和組合,包括歷史數據和更多資訊,讓你找到更有效的投資策略。 於 algo.investbotapp.com -
#65.Alibaba Group ADR / US01609W1027 - SIX Structured Products
Symbol: BABA. ISIN: US01609W1027. Overview. B42779814945657. Data. Name, Alibaba Group ADR. Valor, -. ISIN, US01609W1027. Currency, EUR ... 於 www.six-structured-products.com -
#66.The Spiritual Tourist - Google 圖書結果
In one of these stories, aDr Bannerjee recounts howhe once touchedthe hem of Baba's robe atdarshan, and hisdamaged finger, which was causinghim greatpain, ... 於 books.google.com.tw -
#67.Company DSF Notices - Citi's Depositary Receipt Services
Company, Alibaba Group Holding Limited. Ticker Symbol, BABA. CUSIP Number, 01609W102 (Active). US ISIN, US01609W1027. Country, China. Security Type, ADR. 於 depositaryreceipts.citi.com -
#68.American depositary receipt (ADR) escrow fees - Moomoo
Most of Chinese companies traded on the U.S exchange are ADRs, for example BABA, PDD & NIO etc, these companies will incur regular ADR fees, ... 於 www.moomoo.com -
#69.Alibaba Stock Slammed On Singapore Rumor, But Is BABA ...
Alibaba stock has rallied sharply amid renewed signs of accumulation as investors bet on better times ahead for the Chinese juggernaut. 於 www.investors.com -
#70.ADR Conversions - Interactive Brokers LLC
Ordinary Shares (ORD) ORD Symbol ORD ISIN Ratio (ORD to ADR) ADR... AEGON NV AGN NL0000303709 1 AEG AIA GROUP LTD 1299 HK0000069689 4 AAGIY ALIBABA GROUP HOLDING LTD 9988 KYG017191142 8 BABA 於 www.interactivebrokers.com -
#71.Dervish Dust: The Life and Words of James Coburn
... 238 Aznavour, Charles, 208 Baba Muktananda, 156–57 Backstage (magazine), ... 69 actors' strikes, 61 additional dialogue recording (adr), 183. 於 books.google.com.tw -
#72.Baba q3 earnings 2022
(NYSE: BABA) Q3 2022 Earnings Call Feb 24, 2022, 7:30 a. ... ADR BABA (U. In the last reported quarter, the Chinese e-commerce giant January 30, 2023, ... 於 brandcop.co -
#73.How to convert Alibaba ADRs to Hong Kong Shares
For investors who own Chinese ADRs in companies like Alibaba (Ticker: BABA), the risk of delisting has been persistent since the Trump ... 於 investingintheweb.com -
#74.BABA | Alibaba Group Holding Ltd. ADR Stock Overview (U.S.
Complete Alibaba Group Holding Ltd. ADR stock information by Barron's. View real-time BABA stock price and news, along with industry-best analysis. 於 www.barrons.com -
#75.BABA: Alibaba Group Holding Ltd - Stock Price, Quote ... - CNBC
Get Alibaba Group Holding Ltd (BABA:NYSE) real-time stock quotes, news, price and financial information from CNBC. 於 www.cnbc.com