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市場動盪下之電腦顯示卡供需研究

為了解決BRK. B 盤 前的問題，作者黃千毅 這樣論述：

　　本研究從觀察到近年來個人電腦市場上的顯示卡在價格出現異常上漲以及缺貨的現象，並且在市場上出現二手顯示卡的價格不跌反升的現象，還產生了一種新的零售模式，通路商要求購買顯示卡必需搭機銷售，因此想瞭解顯示卡在個人電腦市場上是否有出現供給與需求失衡情況，並且找出造成市場上顯示卡供給與需求異常的原因。　　分析上依顯示卡市場的供給方與需求方研究，並且經由訪談幾位有使用顯示卡的用戶來瞭解顯示卡市場上所發生的狀況，並通過網路聲量分析來確認網路上民眾對顯示卡缺貨的普遍想法與認知，分析的結果發現顯示卡的供給與需求失衡現象是因為顯示卡的需求量大增，並導致近年來的顯示卡價格大漲以及缺貨現象，其中以加密貨幣挖礦的

需求最為旺盛，礦工在評估能在加密貨幣挖礦獲利的情況下大量買入顯示卡，使得顯示卡價格上漲並且供不應求，此外近年來的疫情關係所衍生的居家工作及遠距線上學習，也使得民眾在家玩電競遊戲的需求提高，也相對提升顯示卡的需求；雖然在供給端也有因為疫情關係而產生的晶片荒現象，但整體來說並沒有對顯示卡供給端造成太大的影響。

探討血癌細胞中活化Lck調控糖解酵素基因表達的分子機轉

為了解決BRK. B 盤 前的問題，作者朱慶渝 這樣論述：

Table of ContentsRecommendation Letter from the Thesis AdvisorThesis/Dissertation Oral Defense Committee CertificationAcknowledgments .................................................................................... iii中文摘要 ........................................................................

...........................ivAbstract......................................................................................................viTable of Contents ................................................................................... viiiList of Figures......................................

......................................................xiList of Tables............................................................................................xiiI. Introduction ........................................................................................ - 1 -Leukemia ................

............................................................................ - 1 -Protein tyrosine kinase and cancer ..................................................... - 1 -Cancer metabolism ............................................................................. - 2 -Lymphocyte-specific tyr

osine kinase ................................................. - 3 -Lck in T-cell development and cancers.............................................. - 4 -Subcellular localization of Lck........................................................... - 4 -II. Research Motivation .......................

.................................................. - 6 -III. Materials and Methods .................................................................... - 7 -Cell culture ......................................................................................... - 7 -Cells treated with Lck kinase inhib

itor............................................... - 7 -Electroporation and establishment of stable cell lines ....................... - 7 -Subcellular fractionation .................................................................... - 8 -Western blot ..............................................

......................................... - 8 -RNA extraction and quantitative PCR ............................................... - 9 -Immunoprecipitation .......................................................................... - 9 -Measurement of metabolites ....................................

........................ - 10 -RNA-sequencing .............................................................................. - 10 -2-NBDG uptake by flow cytometry ................................................. - 11 -Flow cytometric analysis.........................................................

.........-11 -IV. Results ........................................................................................... - 13 -Nuclear translocation of Lck and RNA-sequencing......................... -13 -Establishment of constitutively active Lck cell lines and RNA- sequencing validation. ............

.......................................................... -14 -Inhibition of Lck kinase activity repressed the mRNA expression of glycolytic enzymes. .......................................................................... -15 -Constitutively active Lck regulates protein expression of glycolytic

enzymes through NF-????B activation. ................................................ -15 -Constitutively active Lck regulates glucose uptake and glycolysis pathway ............................................................................................ -16 -Conclusion...........................

.............................................................-17 -V. Discussion....................................................................................... -19 -Nuclear translocation of Lck and RNA-sequencing......................... -19 -Establishment of constitutively active Lck cell li

nes and RNA- sequencing validation. ...................................................................... -19 -Inhibition of Lck kinase activity reduced the mRNA expression of glycolytic enzymes. .......................................................................... -20 -Constitutively active L

ck regulates protein expression of glycolytic enzymes through NF-????B activation. ................................................ -21 -Constitutively active Lck regulates glucose uptake and glycolysis pathway .........................................................................................

... -23 -VI. Figures and Tables ........................................................................ - 25 -VII. References ......................................................... - 41 -VIII. Supplementary Information..............................................................................

.... -49 -List of FiguresFigure 1. Subcellular localization of Lck in Jcam and Jcam WT Lck cells. ...................................................................................................... - 25 -Figure 2. Altered glycolysis from KEGG pathway analysis of RNA- sequencing data..............

............................................................... - 26 -Figure 3. Validation of mRNA expression of three glycolytic enzymes by real-time qPCR analysis. .............................................................. - 27 -Figure 4. Validation of stable cell lines expressing constitutive

ly active Lck. ............................................................................................... - 28 -Figure 5. Analysis of mRNA and protein expression of three glycolytic enzyme in EL4 Y505FLck cells. .................................................. - 29 -Figure 6. Phosphorylation

of Lck and Src in EL4 Y505FLck cells treated with Lck kinase............................................................................. - 30 -Figure 7. Correlation of Lck kinase activity and gene expression of glycolytic enzymes in Jcam WTLck cells. ................................... - 31 -Figure

8. Correlation of Lck kinase activity and gene expression of glycolytic enzymes in Jcam Y505FLck cells. .............................. - 32 -Figure 9. Increased NF-????B activation in EL4 Y505FLck cells........... - 33 -Figure 10. Increased levels of glycolytic metabolites in EL4 Y505FLck cells. ..

............................................................................................ - 34 -Figure 11. Upregulation of GLUT1 expression and glucose uptake in cells expressing constitutively active Lck............................................. - 35 -Figure 12. A model of Lck-induced activat

ion of glycolytic metabolism through the NF-????B pathway. ........................................................ - 36 -List of TablesTable 1. Candidates of RNA-sequencing l with fold change cut-off value 1 or -1 ±1 in Jcam and Jcam WT Lck treated with pervanadate. - 40 -