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探討組蛋白去乙醯酶抑制劑於癌症治療的藥理機轉

為了解決BT l stock的問題，作者張庭瑜 這樣論述：

癌症是破壞染色質結構和基因體功能的遺傳和表觀遺傳改變所導致的結果。目前已經有數種表觀遺傳抗癌藥物被核可並使用於臨床治療如組蛋白去乙醯酶抑製劑 (histone deacetylase inhibitors; HDACi)。然而，患有固態腫瘤的病人對於HDACi的反應差異性很大。為了提高HDACi的抗癌功效，我測試了依據第一類HDAC抑制劑entinostat的結構而設計的一系列小分子化合物。化合物A14 具有較高的細胞毒性，而其機制與entinostat相似，均可使得細胞週期停滯於G1期並引發細胞凋亡。相對地，另一個化合物MPT0L184可降低細胞週期檢查點激酶的活性並使得細胞提早產生細胞分

裂訊號，最終使已複製完成的細胞無法進入分裂時期。同時，我也發現化合物B7/B15是細胞分裂的抑制劑，其能抑制HDAC的活性並擾亂微小管的聚合作用。重要的是，具有entinostat抗性的胃癌細胞對於這些衍生物的敏感性增加，表示這些衍生物有可能可以克服HDAC抑制劑的抗性。綜合以上結果，我的研究發現一系列eninostat衍生物是具有克服HDAC抑制劑抗藥性潛力的抗癌藥物。

氣候變異、生計多樣化與農業家戶糧食安全：孟加拉的實證研究

為了解決BT l stock的問題，作者松浦　正典 這樣論述：

Climate variability has become much more obvious as a result of global climate change. Livelihood diversification including crop and income diversification is one of the most remarkable strategies to manage risk and cope with economic and climate shocks in order to improve rural livelihood. We inve

stigate the empirical linkages among climate variability, livelihood diversification, and household food security, exploiting three waves of nationally representative rural household panel data merged with granular climate data in Bangladesh. Using control function approach and IV regression to cont

rol for possible endogeneity of livelihood diversification, we find that seasonal rainfall shock and temperature shock affect livelihood diversification, then livelihood diversification improves household food security. Taken together, the results suggest that promoting the diversification strategie

s through investing in socio-economic factors, institutional conditions, and infrastructure., thus they can help to address the food insecurity of farmers under climate change in Bangladesh.