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Orthogonal Polynomials

為了解決Rapid的問題，作者Rakhmanov, Evguenii A. 這樣論述：

The series is devoted to the publication of monographs and high-level textbooks in mathematics, mathematical methods and their applications. Apart from covering important areas of current interest, a major aim is to make topics of an interdisciplinary nature accessible to the non-specialist. The

works in this series are addressed to advanced students and researchers in mathematics and theoretical physics. In addition, it can serve as a guide for lectures and seminars on a graduate level. The series de Gruyter Studies in Mathematics was founded ca. 35 years ago by the late Professor Heinz Ba

uer and Professor Peter Gabriel with the aim to establish a series of monographs and textbooks of high standard, written by scholars with an international reputation presenting current fields of research in pure and applied mathematics.While the editorial board of the Studies has changed with the ye

ars, the aspirations of the Studies are unchanged. In times of rapid growth of mathematical knowledge carefully written monographs and textbooks written by experts are needed more than ever, not least to pave the way for the next generation of mathematicians. In this sense the editorial board and th

e publisher of the Studies are devoted to continue the Studies as a service to the mathematical community.Please submit any book proposals to Niels Jacob.

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An Integrated Approach For Uncovering Novel DNA Methylation Biomarkers For Non-small Cell Lung Carcinoma

為了解決Rapid的問題，作者VAIBHAV KUMAR SUNKARIA 這樣論述：

Introduction - Lung cancer is one of primal and ubiquitous cause of cancer related fatalities in the world. Leading cause of these fatalities is non-small cell lung cancer (NSCLC) with a proportion of 85%. The major subtypes of NSCLC are Lung Adenocarcinoma (LUAD) and Lung Small Cell Carcinoma (LUS

C). Early-stage surgical detection and removal of tumor offers a favorable prognosis and better survival rates. However, a major portion of 75% subjects have stage III/IV at the time of diagnosis and despite advanced major developments in oncology survival rates remain poor. Carcinogens produce wide

spread DNA methylation changes within cells. These changes are characterized by globally hyper or hypo methylated regions around CpG islands, many of these changes occur early in tumorigenesis and are highly prevalent across a tumor type.Structure - This research work took advantage of publicly avai

lable methylation profiling resources and relevant comorbidities for lung cancer patients extracted from meta-analysis of scientific review and journal available at PubMed and CNKI search which were combined systematically to explore effective DNA methylation markers for NSCLC. We also tried to iden

tify common CpG loci between Caucasian, Black and Asian racial groups for identifying ubiquitous candidate genes thoroughly. Statistical analysis and GO ontology were also conducted to explore associated novel biomarkers. These novel findings could facilitate design of accurate diagnostic panel for

practical clinical relevance.Methodology - DNA methylation profiles were extracted from TCGA for 418 LUAD and 370 LUSC tissue samples from patients compared with 32 and 42 non-malignant ones respectively. Standard pipeline was conducted to discover significant differentially methylated sites as prim

ary biomarkers. Secondary biomarkers were extracted by incorporating genes associated with comorbidities from meta-analysis of research articles. Concordant candidates were utilized for NSCLC relevant biomarker candidates. Gene ontology annotations were used to calculate gene-pair distance matrix fo

r all candidate biomarkers. Clustering algorithms were utilized to categorize candidate genes into different functional groups using the gene distance matrix. There were 35 CpG loci identified by comparing TCGA training cohort with GEO testing cohort from these functional groups, and 4 gene-based pa

nel was devised after finding highly discriminatory diagnostic panel through combinatorial validation of each functional cluster.Results – To evaluate the gene panel for NSCLC, the methylation levels of SCT(Secritin), FOXD3(Forkhead Box D3), TRIM58(Tripartite Motif Containing 58) and TAC1(Tachikinin

1) were tested. Individually each gene showed significant methylation difference between LUAD and LUSC training cohort. Combined 4-gene panel AUC, sensitivity/specificity were evaluated with 0.9596, 90.43%/100% in LUAD; 0.949, 86.95%/98.21% in LUSC TCGA training cohort; 0.94, 85.92%/97.37 in GEO 66

836; 0.91,89.17%/100% in GEO 83842 smokers; 0.948, 91.67%/100% in GEO83842 non-smokers independent testing cohort. Our study validates SCT, FOXD3, TRIM58 and TAC1 based gene panel has great potential in early recognition of NSCLC undetermined lung nodules. The findings can yield universally accurate

and robust markers facilitating early diagnosis and rapid severity examination.

Quantitative Literary Analysis of Aphra Behn’’s Works

為了解決Rapid的問題，作者Runge, Laura L. 這樣論述：

Aphra Behn (1640-1689), prolific and popular playwright, poet, novelist, and translator, has a fascinating and extensive corpus of literature that plays a key role in literary history. The book offers an analysis of all of Behn’s literary output. It examines the author’s use of words in terms of

frequencies and distributions, and stacks the oeuvre in order to read Behn’s word usage synchronically. This experimental analysis of Behn’s literary corpus aims to provide a statistical overview of Behn’s writing and a study of her works according to the logic of the concordance. The analysis demon

strates the interpretive potential of digital corpus work, and it provides a fascinating reading of synchronic patterns in Behn’s writing. The book aims to augment the practice of close-reading by facilitating the rapid moves from full corpus to unique subsets, individual texts, and specific passage

s. It facilitates the connections among works that share verbal structures that would otherwise not register in diachronic reading. Each chapter focuses on one type of writing: poetry, drama, and prose. The chapters begin with an overview of the documents that make up the corpus for the genre (e.g.

the 80 published poems attributed to Behn in her lifetime; 18 plays and 12 prose works). A section on statistical commonplaces follows (length of texts, vocabulary density, and most frequent words). Interesting textual examples are explored in more detail for provocative close readings. The statisti

cs then are contextualized with the general language reference corpus for a discussion of keywords. Each chapter features a unique comparative study that illustrates Behn in a specific context. Each chapter analyzes a specific genre and comparative statistical experiments within the genre. The concl

usion compares all three genres to provide a study of Aphra Behn’s oeuvre as a whole. The discussion is focused through the lens of Behn’s most remarkable words. The keywords for her oeuvre as compared to the literary works in the general language reference (fifteen texts) when the proper names and

stage directions are removed to provide an index of Behn’s characteristic themes and qualities: oh, young, lover, love, marry, charming, heart, gay, soft, goes. Each of these words opens a window on her corpus as a whole. A unique case study of a significant author using new literary methodologies,

this book provides an appealing snapshot of Behn’s whole career informed by deep knowledge of the Restoration era and developments in digital humanities and cultural analytics.

優化採購管理之實務研究

為了解決Rapid的問題，作者陳美芳 這樣論述：

電子製造業面對半導體物料交期的不確定性、訂單給予供應商前置時間（Lead Time）不足、臨時更改設計、客戶端的需求變化瞬息萬變加上不可抗力的偶發事件和天災人禍在在考驗管理者的因應能力。藉由個案公司了解可能面臨的供應鏈危機接續不上，如何降低生產線停工的危機及後續損失賠償降到最低。本研究期可提供企業優化現有的採購作業流程，持續改善採購管理效率之建議，並建議品牌廠商採購管理應著重於如何與供應商、外包廠商建立長期夥伴關係，進而持續改善作業流程及降低成本、提升企業採購總體績效，並且能讓企業對緊急訂單需求作出更快速的反應。在本研究討論中，透過對個案公司降低供應鏈風險增進採購效率的觀念探討分析，從而得出

結論，採購經過資訊系統協助更可達成風險共擔與資訊共享觀念，風險成本及代工廠轉運成本均可下降、對前置時間不足的緊急訂單應變能力提升。