Consolidate的問題，透過圖書和論文來找解法和答案更準確安心。 我們找到下列股價、配息、目標價等股票新聞資訊

Ralph Johnson: Complete Works

為了解決Consolidate的問題，作者Johnson, Ralph 這樣論述：

- Provides a comprehensive insight into the complete works of global design and innovation by the prolific industry giant, Ralph Johnson from Perkins+Will- Presents a vivid and yielding portrayal of Ralph Johnson's sense of modernism, with informative essays, in-depth conversations and narrative des

criptions of each design- Features several hundred pages of detailed study, rich, full-color photographs, sketches, illustrations and plans - Augments IMAGES' wide collection of monographs on this current master, whose work spans many decadesNOTABLE PROJECTS Shanghai Natural History Museum, Shanghai

, China O'Hare International Airport Terminal, Chicago, Illinois The Johns Hopkins Hospital New Clinical Building, Baltimore, Maryland Tianjin Museum, Tianjin, China Boeing World Headquarters, 100 N Riverside Plaza, Chicago, Illinois Arizona State University--Science and Technology Building 1, Tempe

, Arizona Case Western Reserve University, Tinkham Veale University Center, Cleveland, Ohio Ralph Johnson's work spans a magnificent range of award-winning projects--in terms of both location and program types, with each project being distinct yet consistent in an underlying process and design inten

t. From a residential high-rise in Chicago, to a university in Africa, to a museum in a park in Asia, Johnson's work is environmentally responsible and uniquely suited to the particular needs of the client, climate, and site. The beautifully presented works in this stunning monograph include both bu

ilt and unbuilt projects and their significance is underpinned by Johnson's deep-held respect for humanistic values and his emphasis on process rather than preconceived product, allowing the work to respond to diverse cultures and urban conditions. Johnson is widely acclaimed for the complexity of h

is designs that incorporate dynamism with modern forms that meaningfully consolidate the surrounding urban fabric and identity and landscape contexts. This 600-page monograph is a comprehensive account of Johnson's long career and features striking examples of Johnson's highly detailed illustrations

and renderings, along with rich, full-color photographs to chronicle his impressive folio of work. This distinguished volume sits comfortably in the heady realm of IMAGES' highly anticipated 21st Century Masters series, which celebrates international juggernauts in the fields of architecture and de

sign. Ralph Johnson is a Principal and Global Design Director at Perkins+Will, where he has worked since 1976. He was elected to the College of Fellows of the American Institute of Architects in 1995, and was elected to the National Academy in 2015 - one of the highest honours in American art and

architecture.

Consolidate進入發燒排行的影片

蔬食餐廳的關鍵成功因素-以宜蘭為例

為了解決Consolidate的問題，作者游仲喆 這樣論述：

隨著新時代的飲食習慣改變與環境保護議題被更多人重視，吃蔬食的人口已逐漸改變，從主流的民間宗教信仰逐漸轉變成多元因素，吃蔬食已經成為一種養身、愛護地球、潮流的化身，越來越多人加入蔬食的行列，隨著吃蔬食人的增加，蔬食餐廳也日益增多，但是卻有不少餐廳因為某些因素導致餐廳經營不順，最後歇業收場，因此如何正確的經營一間蔬食餐廳，以及成功的蔬食餐廳應該具備哪些因素，成了一個很重要影響關鍵。本研究在探討宜蘭蔬食餐廳的關鍵成功因素，首先透過文獻蒐集，蒐集相關的文獻初步擬定其構面與評估準則，接著運用修正式德菲法，彙整聚攏專家、學者意見，找出蔬食餐廳的關鍵成功因素構面與評估準則，並進一步建構層級分析架構，接著使

用層級分析法(AHP)進行問卷調查，調查宜蘭的蔬食餐廳消費者對於蔬食餐廳的關鍵成功因素看法，針對各評估準則進行權重分析，建構出宜蘭蔬食餐廳的關鍵成功因素的權重體系。本研究結果得知，宜蘭蔬食餐廳的關鍵成功因素之主要構面權重依序為:先決條件、行銷方式、供給餐點、顧客感受。以評估準則權重前五來看依序為:「經營者」、「資本額」、「廣告」、「餐廳地點」、「餐點種類」。本研究結果可提供給宜蘭蔬食餐廳業者做為參考，亦可作為宜蘭蔬食餐廳創業者做為參考，制定蔬食餐廳的經營、管理方法。

Building a Body of Knowledge in Construction Project Delivery, Procurement and Contracting

為了解決Consolidate的問題，作者 這樣論述：

This book aims to consolidate, structure and articulate collective knowledge on construction project delivery, procurement and contracting, so that it can serve as a gateway to the contiguous topics of construction project delivery. In addition to supporting the education of student researchers,

as well as broadening and deepening the knowledge of practitioners, the book is also intended to serve as a foundation for future education and as a reference book. Academicians can use it to benchmark and support their research and also as a textbook for an undergraduate or graduate course on the t

opics of project delivery, procurement and contracting.

T細胞酪胺酸去磷酸酶的異位調控：無結構區域造成之自我活性抑制及整聯蛋白alpha-1碳端所促進之酵素活化

為了解決Consolidate的問題，作者辛杰培 這樣論述：

T細胞的蛋白酪胺酸磷酸水解酶 (TCPTP, PTPN2) 是在人體細胞中普遍表達的一種非受體型蛋白酪胺酸磷酸水解酶，在不同的細胞間室中有多種不同的作用受質。它調控關鍵訊息傳遞路徑，並與各種癌症生成、發炎反應以及其他人類疾病的發生息息相關。因此，了解TCPTP活性調控的分子機制對於開發針對TCPTP的治療方法至關重要，然而以結構基礎來詮釋TCPTP活性調控機制仍然難以捉摸。在本研究中，我們結合生物物理學以及生物化學的研究方法，進行全面性結構分析，闡明TCPTP活性調控的分子機制。由於TCPTP和PTP1B在PTP家族中是最接近的同源物，可以假設此兩種磷酸水解酶的活性調控是相似的。因此，我們首

先透過X 射線晶體學來探討TCPTP的活性調控是否也存在在PTP1B的變構位點。在解析度分別為1.7Å及1.9Å的TCPTP晶體結構中，我們都觀察到C 端的螺旋 α7。螺旋 α7在PTP1B上是具有功能性且被確定為其變構開關，然而過往研究並未解析螺旋 α7在TCPTP中的功能。此論文中，我們首次證明螺旋 α7發生截斷或刪除時，TCPTP的催化效率會下降約四倍。整體來說，我們的結果證明螺旋 α7的變構角色在TCPTP活性調控之功能與PTP1B相似，且強調螺旋 α7和主要的催化區域的協調對於TCPTP的有效催化功能是必要的。根據晶體結構的觀察分析，我們提出更進一步的問題: 如果TCPTP和PTP1

B的活性催化調控相似，那該如何區分兩者之間活性調控的專一性? 此一問題的釐清對開發TCPTP的藥物有其必要，因此我們繼續專注地研究TCPTP非催化的C側尾端的活化調控。先前的研究已提出TCPTP被自身的C端滅活的假設，但如何造成此結果則仍未知。此外，如果TCPTP表現後無活性，那其如何在細胞內被激活?為了回答這些問題，我們使用核磁共振 (NMR)光譜學、小角度 X 射線散射 (SAXS)以及化學交聯與質譜偶合 (CX-MS)為主要的工具來闡示TCPTP的尾端無結構序列做為分子內自動抑制其酵素活性機制的主要工具。然而，這並不是靠靜態作用造成，而是C端尾部在活化位點周圍移動，以動態遮擋TCPTP的

基質，就像是汽車的”擋風玻璃雨刷”一般的機制。 再者，TCPTP活化是藉由細胞內的競爭來達成，意即Integrin-alpha1無結構尾端序列取代了TCPTP的活性抑制尾端，導致TCPTP的完全活化。我們的工作不僅定義了調控TCPTP活性獨特的機制，同時揭露了兩個極度相近的PTPs (PTP1B與TCPTP) 利用其尾端無結構序列經由截然不同的機制調控其酵素活性。這種獨特的調控機制可以用以發展針對TCPTP專一的治療方式。